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Hypoxia-inducible Factor-1alpha: Molecular-targeted Therapy for Hepatocellular Carcinoma

[ Vol. 13 , Issue. 9 ]

Author(s):

Z. Z. Dong, M. Yao, L. Wang, W. Wu, X. Gu and D. F. Yao   Pages 1295 - 1304 ( 10 )

Abstract:


Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of HCC. The importance role of HIF-1α expression in HCC may improve the prognostic and therapeutic technique. This article reviews the HIF-1α expression and its gene during the rat HCC development, the level of HIF-1α expression in HCC patients, and the effect of silencing HIF-1α gene by miRNA on inhibition of HepG2 cell proliferation.

Keywords:

Hepatocellular carcinoma, hypoxia-inducible factor-1alpha, vascular endothelial growth factor, angiopoietin-2, and molecular-targeted therapy.

Affiliation:

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu Province 226001, China.



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