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Computational Methods in Determination of Pharmacophore Models of 5-HT1A, 5-HT2A and 5-HT7 Receptors

[ Vol. 13 , Issue. 7 ]

Author(s):

Anna Bielenica, Anna E. Koziol and Marta Struga   Pages 933 - 951 ( 19 )

Abstract:


The present paper discusses models of 5-HT1A and 5-HT2A receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT7 receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.

Keywords:

arylpiperazine, pharmacophore model, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.

Affiliation:

Department of Medical Chemistry, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.



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