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Catalytic Asymmetric Synthesis of γ-Butenolides by Direct Vinylogous Reactions

[ Vol. 13 , Issue. 6 ]

Author(s):

Lin Yan, Xiaohong Wu, Hongjun Liu, Liangying Xie and Zhiyong Jiang   Pages 845 - 853 ( 9 )

Abstract:


The γ-butenolide structural motif is a prominent feature in many bioactive natural products and drugs. This short review summarizes catalytic asymmetric synthesis of γ-butenolides through direct vinylogous reactions by metal complexes and organocatalysts. In light of building chiral γ-tertiary and quaternary carbon centers of butenolides, three synthetic strategies are included: 1) the reactions with furanone derivatives as nucleophiles, 2) olefination of γ,γ- disubstituted butenolides and 3) the reactions by using γ,γ-disubstituted butenolides as nucleophiles.

Keywords:

Asymmetric synthesis, Vinylogous, Butenolides

Affiliation:

Institute of Chemical Biology, Henan University, Kaifeng, Henan 475004, China.



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