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Angiogenesis as a therapeutic target in breast cancer

[ Vol. 12 , Issue. 12 ]


Angelos K. Koutras, Ioannis Starakis, Dionysia Lymperatou and Haralabos P. Kalofonos   Pages 1230 - 1238 ( 9 )


Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients with advanced breast cancer. This review presents an update on the role of bevacizumab, as well as other anti-angiogenic agents in the management of patients with breast carcinoma.


Angiogenesis, bevacizumab, breast cancer, treatment.


Division of Oncology, Department of Medicine, University Hospital of Patras, 26504 Rion-Patras, Greece

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