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Dithiocarbamate complexes as radiopharmaceuticals for medical imaging

[ Vol. 12 , Issue. 12 ]

Author(s):

David J. Berry, Rafael Torres Martin de Rosales, Putthiporn Charoenphun and Philip J. Blower   Pages 1174 - 1183 ( 10 )

Abstract:


Over the past 30 years dithiocarbamate ligands have found application in radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast majority of research and applications, and the widest range of complex structures, have involved radionuclides of technetium and rhenium. Considering the extent of coordination chemistry of dithiocarbamate ligands described elsewhere in this issue, the extent of radiopharmaceutical application with metallic radionuclides is surprisingly narrow. Here we summarise the types of radiopharmaceutical complexes studied and the uses, and potential uses, to which they have been put in nuclear medicine.

Keywords:

Copper, dithiocarbamate, nuclear medicine, radiopharmaceuticals, rhenium, technetium.

Affiliation:

King’s College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK



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